A biodegradable amphiphilic poly(aminoester) dendrimer for safe and effective siRNA delivery
Chi Ma, Dandan Zhu, Wenyi Lin, Ying Li, Yuanzheng Huang, Huiling Zhu, Mengyun Ye, Yang Wang, Ling Peng, Xiaoxuan Liu
Abstract
Small interfering RNA (siRNA)-based therapeutics represent a novel and compelling drug modality, provided that safe and competent vectors are available for their delivery. Here, we report a biodegradable amphiphilic poly(aminoester) dendrimer for effective siRNA delivery. This dendrimer is readily biodegradable upon enzyme action, and harnesses the delivery features of both lipid and polymer vectors thanks to its lipid/dendrimer hybrid structure. This study opens new perspectives for developing biodegradable and biocompatible vectors for siRNA therapeutics.
Topics & Concepts
DendrimerAmphiphileBiocompatible materialSmall interfering RNADrug deliveryChemistryBiodegradable polymerNanotechnologyPolymerMaterials scienceBiomedical engineeringRNACopolymerPolymer chemistryBiochemistryOrganic chemistryEngineeringGeneRNA Interference and Gene DeliveryDendrimers and Hyperbranched PolymersAdvanced biosensing and bioanalysis techniques