Enol-mediated delivery of H<sub>2</sub>Se from γ-keto selenides: mechanistic insight and evaluation
Rynne A. Hankins, Molly E. Carter, Changlei Zhu, Chen Chen, John C. Lukesh
Abstract
Like hydrogen sulfide (H 2 S), its chalcogen congener, hydrogen selenide (H 2 Se), is an emerging biomolecule of interest. Therefore, small molecule donors that effectively increase its bioavailability are desired to further probe H 2 Se chemical biology.
Topics & Concepts
ChalcogenSelenideBiomoleculeEnolBioavailabilityChemistryMoleculeHydrogen sulfideSeleniumNanotechnologyCombinatorial chemistryMaterials scienceBiochemistryOrganic chemistryBioinformaticsBiologyCatalysisSulfurSulfur Compounds in BiologyOrganoselenium and organotellurium chemistrySelenium in Biological Systems