KnowVolution of prodigiosin ligase PigC towards condensation of short-chain prodiginines
Stefanie Brands, Hannah U. C. Brass, Andreas Klein, Jarno G. Sikkens, Mehdi D. Davari, Jörg Pietruszka, Anna Joëlle Ruff, Ulrich Schwaneberg
Abstract
One round of KnowVolution enhanced the catalytic activity of prodigiosin ligase PigC with short-chain monopyrroles, opening access to anticancer prodiginines.
Topics & Concepts
ProdigiosinChemistryCondensationChain (unit)DNA ligaseUbiquitin ligaseBiochemistryDNAUbiquitinPhysicsSerratia marcescensThermodynamicsGeneEscherichia coliAstronomyMicrobial Metabolism and ApplicationsPharmacological Effects of Natural CompoundsMicrobial Natural Products and Biosynthesis