Metabolomic profiling demonstrates evidence for kidney and urine metabolic dysregulation in a piglet model of cardiac surgery-induced acute kidney injury
Jesse Davidson, Justin Robison, Ludmila Khailová, Benjamin S. Frank, James Jaggers, Richard J. Ing, Scott Lawson, John Iguidbashian, Eiman Ali, Amy Treece, Danielle E. Soranno, Suzanne Osorio Lujan, Jelena Klawitter
Abstract
This project explored the metabolic underpinnings of postoperative acute kidney injury (AKI) following pediatric cardiac surgery in a translationally relevant large animal model of cardiopulmonary bypass with deep hypothermic circulatory arrest. Here, we present novel evidence for dysregulated tryptophan catabolism and purine catabolism in kidney tissue and increased urinary glycolysis intermediates in animals who developed histological AKI. These pathways represent potential diagnostic and therapeutic targets for postoperative AKI in this high-risk population.