Natural Compound from Olive Oil Inhibits S100A9 Amyloid Formation and Cytotoxicity: Implications for Preventing Alzheimer’s Disease
Manuela Leri, Himanshu Chaudhary, Igor A. Iashchishyn, Jonathan Pansieri, Željko M. Svedružić, Silvia Gómez Alcalde, Greta Musteikytė, Vytautas Smirnovas, Massimo Stefani, Monica Bucciantini, Ludmilla A. Morozova‐Roche
Abstract
. Since S100A9 is both a pro-inflammatory and amyloidogenic protein, OleA may effectively mitigate the pathological consequences of the S100A9-dependent amyloid-neuroinflammatory cascade as well as provide protection from neurodegeneration, if used within the Mediterranean diet as a potential preventive measure.
Topics & Concepts
OleaAmyloid (mycology)ThioflavinChemistryAmyloid diseaseBiochemistryBiophysicsBiologyAlzheimer's diseasePathologyAmyloid fibrilMedicineAmyloid βPaleontologyInorganic chemistryDiseaseAlzheimer's disease research and treatmentsS100 Proteins and AnnexinsAdvanced Glycation End Products research