Loss-of-function mutations in Dnmt3a and Tet2 lead to accelerated atherosclerosis and concordant macrophage phenotypes
Philipp J. Rauch, Jayakrishnan Gopakumar, Alexander J. Silver, Daniel Nachun, Herra Ahmad, Marie McConkey, Tetsushi Nakao, Marc Bossé, Thiago Rentz, Nora Vivanco Gonzalez, Noah F. Greenwald, Erin McCaffrey, Zumana Khair, Manu Gopakumar, Kameron B. Rodrigues, Amy E. Lin, Eti Sinha, Maia Fefer, Drew N. Cohen, Amélie Vromman, Eugenia Shvartz, Galina K. Sukhova, Sean C. Bendall, Michael Angelo, Peter Libby, Benjamin L. Ebert, Siddhartha Jaiswal
Topics & Concepts
PhenocopyBiologyLoss functionInflammationImmunologyPhenotypeCancer researchMacrophageMyeloidGermline mutationEpigeneticsImmune systemPopulationInnate immune systemHaematopoiesisMutationGeneticsMedicineGeneIn vitroStem cellEnvironmental healthAcute Myeloid Leukemia ResearchEpigenetics and DNA MethylationSingle-cell and spatial transcriptomics