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Loss-of-function mutations in Dnmt3a and Tet2 lead to accelerated atherosclerosis and concordant macrophage phenotypes

Philipp J. Rauch, Jayakrishnan Gopakumar, Alexander J. Silver, Daniel Nachun, Herra Ahmad, Marie McConkey, Tetsushi Nakao, Marc Bossé, Thiago Rentz, Nora Vivanco Gonzalez, Noah F. Greenwald, Erin McCaffrey, Zumana Khair, Manu Gopakumar, Kameron B. Rodrigues, Amy E. Lin, Eti Sinha, Maia Fefer, Drew N. Cohen, Amélie Vromman, Eugenia Shvartz, Galina K. Sukhova, Sean C. Bendall, Michael Angelo, Peter Libby, Benjamin L. Ebert, Siddhartha Jaiswal

2023Nature Cardiovascular Research62 citationsDOI

Topics & Concepts

PhenocopyBiologyLoss functionInflammationImmunologyPhenotypeCancer researchMacrophageMyeloidGermline mutationEpigeneticsImmune systemPopulationInnate immune systemHaematopoiesisMutationGeneticsMedicineGeneIn vitroStem cellEnvironmental healthAcute Myeloid Leukemia ResearchEpigenetics and DNA MethylationSingle-cell and spatial transcriptomics
Loss-of-function mutations in Dnmt3a and Tet2 lead to accelerated atherosclerosis and concordant macrophage phenotypes | Litcius