Elevated Ras related GTP binding B (RRAGB) expression predicts poor overall survival and constructs a prognostic nomogram for colon adenocarcinoma
Jianjia Xiao, Qingqing Liu, Weijie Wu, Ying Yuan, Jie Zhou, Jieyu Shi, Shaorong Zhou
Abstract
< 0.05). GSEA identified five signaling pathways significantly enriched in the high-RRAGB expression phenotype. Moreover, a RRAGB-based nomogram was successfully constructed and displayed a satisfactory performance. In addition, RRAGB expression was found to be significantly associated with microsatellite instability (MSI), tumor mutational burden (TMB) and immunity. Our results revealed that RRAGB could be a prognostic biomarker for COAD in terms of OS and markedly related to MSI, TMB, and immunity. We also constructed an RRAGB-based nomogram with a satisfactory performance. Further researches should be carried out to validate our findings.
Topics & Concepts
NomogramProportional hazards modelColorectal cancerBiologyOncologyMicrosatellite instabilityUnivariateMultivariate analysisSurvival analysisMultivariate statisticsInternal medicineGeneCancerMedicineGeneticsMicrosatelliteAlleleMathematicsStatisticsFerroptosis and cancer prognosisRNA modifications and cancerCancer-related molecular mechanisms research