Cobalt(II)‐Catalyzed C(sp <sup>3</sup> )−C(sp <sup>3</sup> ) Coupling for the Direct Stereoselective Synthesis of 2‐Deoxy‐ <i>C</i> ‐Glycosides from Glycals
Mingjie Zeng, Changyue Yu, Yibing Wang, Jingjing Wang, Jingjing Wang, Jiang Wang, Jiang Wang, Hong Liu
Abstract
) coupling hydroalkylation for direct and β-selective synthesis of 2-deoxy-C-glycosides from glycals. This reaction proceeds by a radical pathway for alkyl halide activation and is β-selective through ligand control. This approach may inspire the development of further stereoselective coupling reactions with potential application in the field of carbohydrates.
Topics & Concepts
StereoselectivityChemistryLigand (biochemistry)CatalysisCobaltHalideStereochemistryCoupling reactionGlycosideCoupling (piping)Medicinal chemistryOrganic chemistryMaterials scienceReceptorBiochemistryMetallurgyCarbohydrate Chemistry and SynthesisFluorine in Organic ChemistryMicrobial Natural Products and Biosynthesis