Difunctionalization Processes Enabled by Hexafluoroisopropanol
Maciej Piejko, Joseph Moran, David Lebœuf
Abstract
In the past 5 years, hexafluoroisopropanol (HFIP) has been used as a unique solvent or additive to enable challenging transformations through substrate activation and stabilization of reactive intermediates. In this Review, we aim at describing difunctionalization processes which were unlocked when HFIP was involved. Specifically, we focus on cyclizations and additions to alkenes, alkynes, epoxides, and carbonyls that introduce a wide range of functional groups of interest.
Topics & Concepts
Substrate (aquarium)SolventCombinatorial chemistryChemistryFocus (optics)Organic chemistryPhysicsBiologyOpticsEcologyFluorine in Organic ChemistryAsymmetric Synthesis and CatalysisCatalytic C–H Functionalization Methods