Litcius/Paper detail

4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments

Mahmoud A. Ragab, Wagdy M. Eldehna, Alessio Nocentini, Alessandro Bonardi, Hazem Essam Okda, Bahaa Elgendy, Tarek S. Ibrahim, Mohammad M. Abd‐Alhaseeb, Paola Gratteri, Claudiu T. Supuran, Ahmed A. Al‐Karmalawy, Mohamed Elagawany

2023European Journal of Medicinal Chemistry53 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryCarbonic anhydraseMoietyGene isoformPyrazoleIC50Inhibitory postsynaptic potentialStereochemistryIsozymeIn vitroEnzymeBiochemistryNeuroscienceGeneBiologyEnzyme function and inhibitionSynthesis and biological activitySynthesis and Catalytic Reactions