4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments
Mahmoud A. Ragab, Wagdy M. Eldehna, Alessio Nocentini, Alessandro Bonardi, Hazem Essam Okda, Bahaa Elgendy, Tarek S. Ibrahim, Mohammad M. Abd‐Alhaseeb, Paola Gratteri, Claudiu T. Supuran, Ahmed A. Al‐Karmalawy, Mohamed Elagawany
Topics & Concepts
ChemistryCarbonic anhydraseMoietyGene isoformPyrazoleIC50Inhibitory postsynaptic potentialStereochemistryIsozymeIn vitroEnzymeBiochemistryNeuroscienceGeneBiologyEnzyme function and inhibitionSynthesis and biological activitySynthesis and Catalytic Reactions