Insights into therapy resistance in cervical cancer
Irene A. George, Richa Chauhan, R. E. Dhawale, Roshini Iyer, Sewanti Limaye, Rengaswamy Sankaranarayanan, R. Venkataramanan, Prashant Kumar
Abstract
Treatment failure is one of the main hurdles in treating cervical cancer, despite significant breakthroughs in both conventional and targeted therapy. The one-year survival of patients with advanced or recurrent cervical cancer globally is less than 30%. Chemotherapy, radiation, and concurrent chemoradiotherapy are among the therapeutic modalities being used in clinics, depending on the stage of the disease. However, resistance to these treatment methods compromises the efficacy of the overall treatment. Numerous approaches based on prognostic biomarkers and combination therapy with multiple agents may be able to successfully combat treatment resistance in cervical cancer. In this review, we discuss the molecular mechanisms of treatment resistance in cervical cancer.