Cell-loaded injectable gelatin/alginate/LAPONITE® nanocomposite hydrogel promotes bone healing in a critical-size rat calvarial defect model
Bin Liu, Junqin Li, Xing Lei, Sheng Miao, Shuaishuai Zhang, Pengzhen Cheng, Yue Song, Hao Wu, Yi Gao, Long Bi, Guoxian Pei
Abstract
results proved that the hydrogel loaded with rBMSCs significantly promoted bone healing in rat calvarial defects, compared to the hydrogel without cells, and that the hydrogel did not provoked side effects on the recipients. Given these advantageous properties, the developed cell-loaded injectable nanocomposite hydrogel can greatly accelerate the bone healing in critical bone defects, thus providing a clinical potential candidate for orthopedic applications.
Topics & Concepts
GelatinNanocompositeMaterials scienceBiomedical engineeringBone healingWound healingChemistryComposite materialSurgeryMedicineOrganic chemistry3D Printing in Biomedical ResearchBone Tissue Engineering MaterialsHydrogels: synthesis, properties, applications