Viral Delivery of CAR Targets to Solid Tumors Enables Effective Cell Therapy
Amin Aalipour, Fabrice Le Boeuf, Matthew Y. H. Tang, Surya Murty, Federico Simonetta, Alexander X. Lozano, Travis M. Shaffer, John C. Bell, Sanjiv S. Gambhir
Abstract
. In an immunocompetent model of B16 melanoma, this combination markedly delayed tumor growth and improved median survival compared with antigen-mismatched combinations. We also found that CD19 delivery could improve CAR T cell activity against tumor cells that express low levels of cognate antigen, suggesting a potential application in counteracting antigen-low escape. This approach highlights the potential of engineering tumors for effective adoptive cell therapy.
Topics & Concepts
Chimeric antigen receptorOncolytic virusAntigenCD19Cancer researchCell therapyMelanomaCellBiologyImmunotherapyImmunologyVirologyImmune systemTumor cellsGeneticsCAR-T cell therapy researchVirus-based gene therapy researchViral Infectious Diseases and Gene Expression in Insects