ERK signaling mediates resistance to immunomodulatory drugs in the bone marrow microenvironment
Jiye Liu, Teru Hideshima, Lijie Xing, Su Wang, Wenrong Zhou, Mehmet Samur, Tomasz Sewastianik, Daisuke Ogiya, Gang An, Shaobing Gao, Li Yang, Tong Ji, Giada Bianchi, Kenneth Wen, Yu‐Tzu Tai, Nikhil C. Munshi, Paul G. Richardson, Ruben D. Carrasco, Yong Cang, Kenneth C. Anderson
Abstract
KO cells both in vitro and in vivo. Our studies provide the framework for clinical trials of MEK inhibitors to overcome IMiD resistance in the BM microenvironment and improve patient outcome in MM.
Topics & Concepts
MAPK/ERK pathwayBone marrowCancer researchTumor microenvironmentMultiple myelomaSignal transductionBlocking (statistics)Cell biologyImmunologyMedicineBiologyTumor cellsComputer scienceComputer networkMultiple Myeloma Research and TreatmentsProtein Degradation and InhibitorsMelanoma and MAPK Pathways