Analytical quality by design oriented development of the UPLC method for analysing multiple pharmaceutical process intermediates: A case study of Compound Danshen Dripping Pills
Yanni Tai, Dandan Ren, Wanshun Zhao, Haibin Qu, Haoshu Xiong, Xingchu Gong
Topics & Concepts
Quality by DesignChromatographyRepeatabilityChemistryCritical quality attributesPhosphoric acidHigh-performance liquid chromatographyGradient elutionRosmarinic acidCentral composite designAnalyteDesign of experimentsMathematicsResponse surface methodologyParticle sizeOrganic chemistryAntioxidantStatisticsPhysical chemistryBiochemistryTraditional Chinese Medicine AnalysisGinseng Biological Effects and ApplicationsChromatography in Natural Products