Cullin-RING Ligase 4 in Cancer: Structure, Functions, and Mechanisms
Jingyi Cheng, Xin Bin, Zhangui Tang
Abstract
Cullin-RING ligase 4 (CRL4) has attracted enormous attentions because of its extensive regulatory roles in a wide variety of biological and pathological events, especially cancer-associated events. CRL4 exerts pleiotropic effects by targeting various substrates for proteasomal degradation or changes in activity through different internal compositions to regulate diverse events in cancer progression. In this review, we summarize the structure of CRL4 with manifold compositional modes and clarify the emerging functions and molecular mechanisms of CRL4 in a series of cancer-associated events.
Topics & Concepts
CullinUbiquitin ligaseCancerBiologyCancer researchComputational biologyBioinformaticsUbiquitinGeneGeneticsUbiquitin and proteasome pathwaysProtein Degradation and InhibitorsAutophagy in Disease and Therapy