Serum Spermidine in Relation to Risk of Stroke: A Multilevel Study
Liqiang Zheng, Yanxia Xie, Zhaoqing Sun, Rui Zhang, Yanan Ma, Jiahui Xu, Jia Zheng, Qianyi Xu, Li Zhao, Xiaofan Guo, Guozhe Sun, Fuguo Xing, Yingxian Sun, Deliang Wen
Abstract
The relationship between serum spermidine levels and future cardiovascular disease risk has not yet been well elucidated in the general population based on community studies. Using a nested case-control study, we estimated the association between serum spermidine level and future stroke. New stroke cases had higher baseline levels of spermidine than controls [182.8 (141.8–231.5) vs. 152.0 (124.3–193.0), P < 0.001]. After multivariable adjustment, individuals with spermidine ≥ 205.9 nmol/L (T3) higher risks of stroke (HR 5.02, 95% CI 1.58–16.02) with the lowest quartile (< 136.9 nmol/L) as reference. The association between serum spermidine levels and risk of stroke seemed to be consistent and was reproducible in our cross-sectional studies. In addition, comparisons of the areas under receiver operator characteristics curves confirmed that a model including spermidine had better discrimination than without (0.755 vs. 0.715, P = 0.04). Here we report a close relationship exists between serum spermidine levels and risk of stroke.