Salicylaldehyde thiosemicarbazone copper complexes: impact of hybridization with estrone on cytotoxicity, solution stability and redox activity
Tatsiana V. Petrasheuskaya, Márton A. Kiss, Orsolya Dömötör, Tamás Holczbauer, Nóra V. May, Gabriella Spengler, Annamária Kincses, Ana Čipak Gašparović, Éva Frank, Éva A. Enyedy
Abstract
Copper complex of a novel estrone–thiosemicarbazone hybrid with significant cytotoxicity, lipophilicity and solution stability in addition to its structurally related bicyclic analogue.
Topics & Concepts
ChemistrySemicarbazoneSalicylaldehydeLipophilicityCopperCytotoxicityEstroneRedoxBicyclic moleculeCombinatorial chemistryOrganic chemistryStereochemistryIn vitroSchiff baseBiochemistryHormoneMetal complexes synthesis and propertiesCrystal structures of chemical compoundsMetal-Catalyzed Oxygenation Mechanisms