Female C57BL/6N mice are a viable model of aortic aging in women
Abigail G. Longtine, Ravinandan Venkatasubramanian, Melanie C. Zigler, Alexandra Lindquist, Sophia Mahoney, Nathan Greenberg, Nicholas S. VanDongen, Katelyn R. Ludwig, Kerrie L. Moreau, Douglas R. Seals, Zachary S. Clayton
Abstract
Our study demonstrates that with aging, female C57BL/6N mice exhibit higher in vivo aortic stiffness, reduced modulus of elasticity, aortic wall structural and extracellular matrix remodeling, and elevations in systemic inflammation. These changes are largely reflective of those that occur with aging in women. Thus, female C57BL/6N mice are a viable model of human aortic aging and the utility of these animals should be considered in future biomedical investigations.
Topics & Concepts
ElastinInflammationLysyl oxidaseExtracellular matrixInternal medicineEndocrinologyElectrical impedance myographyAortaMedicinePulse wave velocityImmunologyBiologyPathologyCell biologyBlood pressureVasodilationCardiovascular Health and Disease PreventionAtherosclerosis and Cardiovascular DiseasesCardiovascular Disease and Adiposity