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Genetic, structural, and functional characterization of POLE polymerase proofreading variants allows cancer risk prediction

Nadim Hamzaoui, Flora Alarcon, Nicolas Leulliot, Rosine Guimbaud, Bruno Buecher, Chrystelle Colas, Carole Corsini, Grégory Nuel, Benoı̂t Terris, Pierre Laurent‐Puig, Stanislas Chaussade, Marion Dhooge, Clément Madru, Éric Clauser

2020Genetics in Medicine34 citationsDOIOpen Access PDF

Topics & Concepts

GeneticsExonucleaseBiologyDNA polymeraseProofreadingPenetranceColorectal cancerPrimer (cosmetics)CancerCancer researchDNAGenePhenotypeChemistryOrganic chemistryGenetic factors in colorectal cancerDNA Repair MechanismsBRCA gene mutations in cancer
Genetic, structural, and functional characterization of POLE polymerase proofreading variants allows cancer risk prediction | Litcius