People critically ill with COVID-19 exhibit peripheral immune profiles predictive of mortality and reflective of SARS-CoV-2 lung viral burden
Anthony R. Cillo, Ashwin Somasundaram, Feng Shan, Carly Cardello, Creg J. Workman, Georgios D. Kitsios, Ayana T. Ruffin, Sheryl Kunning, Caleb Lampenfeld, Sayali Onkar, Stephanie Grebinoski, Gaurav Deshmukh, Barbara A. Methé, Chang Liu, Sham Nambulli, Lawrence P. Andrews, W. Paul Duprex, Alok V. Joglekar, Panayiotis V. Benos, Prabir Ray, Anuradha Ray, Bryan J. McVerry, Yingze Zhang, Janet Lee, Jishnu Das, Harinder Singh, Alison Morris, Tullia C. Bruno, Dario A.A. Vignali
Abstract
, leading to a higher risk of death. Our analysis suggests a pivotal role for viral-infected myeloid cells and protracted interferon signaling in severe COVID-19.
Topics & Concepts
Immune systemImmunologyInterferonRespiratory tractBiologyDownregulation and upregulationVirologyMyeloidMedicineRespiratory systemGeneGeneticsAnatomyCOVID-19 Clinical Research StudiesLong-Term Effects of COVID-19Single-cell and spatial transcriptomics