TFEB signaling promotes autophagic degradation of NLRP3 to attenuate neuroinflammation in diabetic encephalopathy
Yijia Lin, Lizhen Cheng, Yixin Chen, Wei Li, Qihao Guo, Ya Miao
Abstract
This article delves into the intricate connections between inflammation, autophagy, diabetes, and neurodegeneration, with a particular focus on a disease that is not yet fully understood-diabetic encephalopathy (DE). TFEB emerges as a pivotal regulator in balancing autophagy and inflammation in DE. Our findings highlight the crucial function of the TFEB-mediated autophagy pathway in mitigating inflammatory damage in DE, suggesting a new treatment strategy.
Topics & Concepts
TFEBAutophagyInflammasomeNeuroinflammationMicrogliaCell biologyChemistryCancer researchBiologyInflammationImmunologyBiochemistryApoptosisAutophagy in Disease and TherapyNeuroinflammation and Neurodegeneration MechanismsExtracellular vesicles in disease