Signaling Pathway Mediating Myeloma Cell Growth and Survival
Teru Hideshima, Kenneth C. Anderson
Abstract
The multiple myeloma (MM) bone marrow (BM) microenvironment consists of different types of accessory cells. Both soluble factors (i.e., cytokines) secreted from these cells and adhesion of MM cells to these cells play crucial roles in activation of intracellular signaling pathways mediating MM cell growth, survival, migration, and drug resistance. Importantly, there is crosstalk between the signaling pathways, increasing the complexity of signal transduction networks in MM cells in the BM microenvironment, highlighting the requirement for combination treatment strategies to blocking multiple signaling pathways.
Topics & Concepts
CrosstalkSignal transductionCell biologyHes3 signaling axisMultiple myelomaTumor microenvironmentBone marrowIntracellularCell signalingAutocrine signallingChemistryCancer researchBiologyImmunologyNotch signaling pathwayReceptorTumor cellsBiochemistryOpticsPhysicsMultiple Myeloma Research and TreatmentsPI3K/AKT/mTOR signaling in cancerPeptidase Inhibition and Analysis