CXCR4-enriched T regulatory cells preferentially home to bone marrow and resolve inflammation
Meixian Huang, Ke Zeng, Mi-Ae Lyu, Lucia Masárová, Tara Sadeghi, Christopher R. Flowers, Simrit Parmar
Abstract
show enhanced migration toward CXCL12/SDF1α and a preferential homing to BM resulting in resolution of inflammation.
Topics & Concepts
Homing (biology)Bone marrowCXCR4InflammationImmunologyIL-2 receptorCell biologyRegulatory T cellUmbilical cordChemistryT cellMedicineBiologyCancer researchChemokineImmune systemEcologyT-cell and B-cell ImmunologyChemokine receptors and signalingImmunotherapy and Immune Responses