A facile and practical preparation of <i>P</i>-chiral phosphine oxides
Ronghua Xu, Zhenhua Gao, Yiteng Yu, Yehua Tang, Duanshuai Tian, Tian Chen, Yibing Chen, Guangqing Xu, Enxue Shi, Wenjun Tang
Abstract
A practical and cost-effective synthetic method of P-chiral diarylalkyl, aryldialkyl, and triaryl phosphine oxides by using readily available chiral diphenyl-2-pyrrolidinemethanol as the auxiliary is developed. The long-standing racemization issue during solvolysis has been addressed and well controlled by employing a suitable solvent, a low reaction temperature, and an appropriate reaction time.
Topics & Concepts
RacemizationPhosphineSolvolysisChemistryOrganic chemistryCombinatorial chemistryCatalysisHydrolysisAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and CatalysisChemical Synthesis and Analysis