The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1G93A mice
Diane Ly, Anjila Dongol, Peter Cuthbertson, Thomas V. Guy, Nicholas J. Geraghty, Reece A. Sophocleous, Lucia Sin, Bradley J. Turner, Debbie Watson, Justin J. Yerbury, Ronald Sluyter
Topics & Concepts
Amyotrophic lateral sclerosisMedicineAntagonistCentral nervous systemInternal medicineSpinal cordEndocrinologyMultiple sclerosisGenetically modified mouseRotarod performance testReceptorImmunologyPharmacologyDiseaseTransgeneBiologyPsychiatryBiochemistryGeneMotor activityAmyotrophic Lateral Sclerosis ResearchAdenosine and Purinergic SignalingNerve injury and regeneration