Evodiamine Inhibits Colorectal Cancer Growth via RTKs Mediated PI3K/AKT/p53 Signaling Pathway
Qiao Zheng, Shengnan Jing, Lin Hu, Xiangrui Meng
Abstract
This study confirmed that EVO inhibits the proliferation of CRC cells and promotes cell apoptosis. The possible mechanism of action is inhibiting the expression of the RTK protein family, activating the PI3K/AKT/p53 apoptotic signaling pathway, thereby inhibiting Bcl-2 expression and increasing Bax expression, promoting apoptosis of CRC cells. As a natural product, EVO has very high potential application value.
Topics & Concepts
PI3K/AKT/mTOR pathwayProtein kinase BApoptosisCell growthCell cycleCancer researchSignal transductionChemistryCell cycle checkpointCell biologyDownregulation and upregulationFlow cytometryBiologyMolecular biologyBiochemistryGeneQuinazolinone synthesis and applicationsSynthesis and Biological EvaluationSynthesis and biological activity