Modulation of Aggregation‐Caused Quenching to Aggregation‐Induced Emission: Finding a Biocompatible Polymeric Theranostics Platform for Cancer Therapy
Cheng Wang, Ziyu Wang, Shaoqing Chen, Peng‐Fei Cui, Lin Qiu, Shuwen Zhou, Hua Jiang, Pengju Jiang, Jianhao Wang
Abstract
Dual intramolecular FRET polymers are synthesized via Suzuki coupling and their luminescence characteristics from aggregation-caused quenching (ACQ) to aggregation-induced emission (AIE) is modulated conveniently by adjusting the charged ratios. The finally obtained AIE polymer is further employed to construct doxorubicin loaded nanoparticles as a promising theranostics platform for cancer therapy.
Topics & Concepts
Aggregation-induced emissionLuminescenceQuenching (fluorescence)Intramolecular forceFörster resonance energy transferPolymerDoxorubicinBiocompatible materialNanoparticleMaterials scienceCancer therapyNanotechnologyChemistryFluorescencePhotochemistryCancerOptoelectronicsOrganic chemistryBiomedical engineeringChemotherapyMedicineSurgeryComposite materialQuantum mechanicsPhysicsInternal medicineLuminescence and Fluorescent MaterialsNanoplatforms for cancer theranosticsMolecular Sensors and Ion Detection