Neonatal Enteropathogenic Escherichia coli Infection Disrupts Microbiota-Gut-Brain Axis Signaling
Carly Hennessey, Ciara E. Keogh, Mariana Barboza, Ingrid Brust‐Mascher, Trina A. Knotts, Jessica Sladek, Matteo M. Pusceddu, Patricia Stokes, Gonzalo Rabasa, Mackenzie K. Honeycutt, Olivia Walsh, Rene K. Nichols, Colin Reardon, Mélanie G. Gareau
Abstract
Diarrheal diseases are a leading cause of death in children under the age of 5 years worldwide. Repeated early-life exposures to diarrheal pathogens can result in comorbidities including stunted growth and cognitive deficits, suggesting an impairment in the microbiota-gut-brain (MGB) axis.
Topics & Concepts
BiologyEnteropathogenic Escherichia coliGut–brain axisGut floraImmunologyProinflammatory cytokineNeuroinflammationEnteric nervous systemMicrobiologyInflammationEndocrinologyEscherichia coliBiochemistryGeneGut microbiota and healthInfant Nutrition and HealthCongenital gastrointestinal and neural anomalies