Childhood psychosocial stress is linked with impaired vascular endothelial function, lower SIRT1, and oxidative stress in young adulthood
Nathaniel D.M. Jenkins, Emily M. Rogers, Nile F. Banks, Patrick M. Tomko, Christina M. Sciarrillo, Sam R. Emerson, Ashlee Taylor, T. Kent Teague
Abstract
Our study provides novel evidence that young adult women with moderate-to-severe adverse childhood experience (ACE) exposure present impaired endothelial function and lower circulating sirtuin 1 (SIRT1) concentrations than age-matched controls. However, an 8-wk exercise intervention was unable to augment endothelial function or SIRT1 concentrations in a subset of those with ACEs. Our data suggest that ACEs-related impairments in endothelial function may be secondary to decreased NO bioavailability via SIRT1 and/or oxidative stress-related mechanisms.
Topics & Concepts
Sirtuin 1Oxidative stressEndothelial dysfunctionSirtuinInternal medicineYoung adultMedicineEndocrinologyPsychosocialAdverse effectPhysiologyBiologyPsychiatryAcetylationGeneGeneticsDownregulation and upregulationAdipose Tissue and MetabolismHeart Rate Variability and Autonomic ControlCardiovascular Disease and Adiposity