Combining radial and continuous flow synthesis to optimize and scale-up the production of medicines
Mara Guidi, Sooyeon Moon, Lucia Anghileri, Dario Cambié, Peter H. Seeberger, Kerry Gilmore
Abstract
Rapid, standardized process optimization and development on a radial synthesizer can be directly converted to a dedicated continuous flow process for scale-up, shown for three APIs <italic>via</italic> single- and multistep syntheses and continuous crystallization.
Topics & Concepts
Continuous flowScale (ratio)Process engineeringContinuous productionProcess (computing)Computer scienceFlow (mathematics)MathematicsEngineeringBiochemical engineeringChemical engineeringPhysicsProgramming languageGeometryQuantum mechanicsInnovative Microfluidic and Catalytic Techniques InnovationAnalytical Chemistry and ChromatographyCrystallization and Solubility Studies