Exogenous succinate impacts mouse brown adipose tissue mitochondrial proteome and potentiates body mass reduction induced by liraglutide
Rodrigo S. Gaspar, Jeany Delafiori, Giuliana S. Zuccoli, Victor Corasolla Carregari, Thaís Paulino do Prado, Joseane Morari, Davi Sidarta-Oliveira, Carina Solon, Rodrigo Ramos Catharino, Eliana P. Araújo, Daniel Martins‐de‐Souza, Lı́cio A. Velloso
Abstract
Exogenous succinate induces major changes in brown adipose tissue protein expression affecting particularly mitochondrial respiration and structural proteins. When given exogenously in drinking water, succinate mitigates body mass gain in a rodent model of diet-induced obesity; in addition, when given in association with the glucagon-like peptide-1 receptor agonist, liraglutide, succinate increases body mass reduction promoted by liraglutide alone.
Topics & Concepts
LiraglutideBrown adipose tissueAdipose tissueEndocrinologyAgonistInternal medicineReceptorChemistryMitochondrionProteomeBiologyCell biologyBiochemistryMedicineType 2 diabetesDiabetes mellitusAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesDiet and metabolism studies