Quantification of protein glycation using vibrational spectroscopy
Bethan S. McAvan, Aidan P. France, Bruno Bellina, Perdita E. Barran, Royston Goodacre, Andrew J. Doig
Abstract
of 0.99. We therefore show the scope and potential of Raman spectroscopy as a high throughput quantification method for glycated proteins in solution that could be applied in disease diagnostics, as well as therapeutic protein quality control.
Topics & Concepts
GlycationRaman spectroscopyChemistryFourier transform infrared spectroscopySpectroscopyAnalytical Chemistry (journal)ChromatographyBiochemistryOpticsPhysicsReceptorQuantum mechanicsAdvanced Glycation End Products researchNatural Antidiabetic Agents StudiesBiochemical effects in animals