Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells
Yan Sun, Xiaolin Lin, Bangdong Liu, Yaxuan Zhang, Wěi Li, Sheng Zhang, Falian He, Han Tian, Xun Zhu, Ximeng Liu, Jueheng Wu, Junchao Cai, Mengfeng Li
Abstract
. Together, our findings suggest a possibility of developing new strategies for the prevention and management of HSC aging and related pathological conditions.
Topics & Concepts
HaematopoiesisStem cellHematopoietic stem cellBiologyPhenotypeATF4Cell biologyImmunologyCancer researchUnfolded protein responseGeneticsGeneEndoplasmic reticulumHematopoietic Stem Cell TransplantationAcute Myeloid Leukemia ResearchRenal and related cancers