EZH2 activates CHK1 signaling to promote ovarian cancer chemoresistance by maintaining the properties of cancer stem cells
Yiping Wen, Yaya Hou, Xiaoqing Yi, Si Sun, Jing Guo, Xiaoqi He, Tao Li, Jing Cai, Zehua Wang
Abstract
Our data revealed a previously unidentified functional and mechanistic link between EZH2 levels, CHK1 signaling activation, and ovarian CSCs and provided strong evidence that EZH2 promotes ovarian cancer chemoresistance and recurrence.
Topics & Concepts
CancerCancer stem cellCancer researchOvarian cancerEZH2Stem cellCancer cellBiologyMedicineCell biologyInternal medicineHistoneDNAGeneticsEpigenetics and DNA MethylationCancer Cells and MetastasisMicroRNA in disease regulation