Efficient and Low‐Impact Acetalization Reactions in Deep Eutectic Solvents
Davide Arnodo, Carolina Meazzo, Salvatore Baldino, Marco Blangetti, Cristina Prandi
Abstract
The synthesis of acetals in acidic natural deep eutectic solvents (NADES), in which the solvent itself participates in the catalytic promotion of the reaction, is reported herein. The reaction is performed under feasible conditions, open air, without the need of external additives, catalysts or water-removing techniques, and it is wide in scope. The products are easily recovered, and the reaction medium is fully recycled and reused without weakening of its catalytic activity after 10 times. Remarkably, the entire process has been realized on gram scale.
Topics & Concepts
CatalysisEutectic systemChemistrySolventDeep eutectic solventScope (computer science)Organic chemistryReaction conditionsChemical engineeringCombinatorial chemistryComputer scienceEngineeringProgramming languageAlloyChemical Synthesis and ReactionsIonic liquids properties and applicationsMulticomponent Synthesis of Heterocycles