Ibuprofen use is associated with reduced C-reactive protein and interleukin-6 levels in chronic spinal cord injury
Andrew Park, Dustin Anderson, Ricardo A. Battaglino, Nguyen M. H. Nguyen, Leslie R. Morse
Abstract
Our study suggests that self-reported ibuprofen use may be negatively associated with CRP and IL-6 levels in chronic SCI after adjusting for known confounding factors, and suggests ibuprofen use may be an important, potential variable to consider in future studies focused on systemic inflammation in SCI. Future prospective studies require assessing frequency, duration, and dosage-dependent effects of ibuprofen on systemic markers of inflammation in chronic SCI. These findings may support future clinical trials to determine safety and efficacy of ibuprofen treatment for various outcomes in chronic SCI.
Topics & Concepts
MedicineIbuprofenConfoundingProspective cohort studyC-reactive proteinInternal medicineSpinal cord injurySystemic inflammationCohort studyInflammationCohortClinical trialSpinal cordPharmacologyPsychiatrySpinal Cord Injury ResearchDiabetic Foot Ulcer Assessment and ManagementPeroxisome Proliferator-Activated Receptors