Copper-Catalyzed Cross-Coupling between Alkyl (Pseudo)halides and Bicyclopentyl Grignard Reagents
Claire Andersen, Vincent Ferey, Marc Daumas, Patrick Bernardelli, Amandine Guérinot, Janine Cossy
Abstract
The development of a copper-catalyzed cross-coupling between primary and secondary (pseudo)halides and bicyclopentyl Grignard reagents is reported. Highly strained bicyclopentanes can be cross-coupled with a large panel of primary alkyl mesylates and secondary alkyl iodides. The catalytic system is simple and cheap, and the reaction is general and chemoselective.
Topics & Concepts
HalideChemistryAlkylReagentCatalysisPrimary (astronomy)CopperCoupling (piping)Grignard reagentOrganic chemistryCoupling reactionCombinatorial chemistryMedicinal chemistryMetallurgyAstronomyPhysicsMaterials scienceCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsFluorine in Organic Chemistry