Ruthenium-initiated polymerization of lactide: a route to remarkable cellular uptake for photodynamic therapy of cancer
Nancy Soliman, Luke K. McKenzie, Johannes Karges, E Bertrand, Mickaël Tharaud, Marta Jakubaszek, Vincent Guérineau, Bruno Goud, Marcel Hollenstein, Gilles Gasser, C.M. Thomas
Abstract
and their cellular uptake in HeLa cells was assessed by confocal microscopy and inductively coupled plasma - mass spectrometry (ICP-MS). All nanoparticles showed improved photophysical properties including luminescence and singlet oxygen generation, enhanced cellular uptake and, capitalizing on this, an improved photo-toxicity. Overall, this study demonstrates how it is possible to transform a non-phototoxic PDT PS into an active PS using an easy, versatile polymerization technique.
Topics & Concepts
PhotosensitizerRutheniumPhotodynamic therapyPhototoxicityPolymerizationLactideChemistryPhotochemistryCombinatorial chemistryMaterials scienceCatalysisOrganic chemistryPolymerBiochemistryIn vitroPhotodynamic Therapy Research StudiesClick Chemistry and ApplicationsNanoplatforms for cancer theranostics