The interplay between non-coding RNAs and Wnt/β-catenin signaling pathway in urinary tract cancers: from tumorigenesis to metastasis
Farzad Rahmani, Pegah Safavi, Ayda Fathollahpour, Fatemeh Tanhaye Kalate Sabz, Parastoo Tajzadeh, Mohsen Arefnezhad, Gordon A. Ferns, Seyed Mahdi Hassanian, Amir Avan
Abstract
Non-coding RNAs (ncRNAs) are emerging as important regulators in various pathological conditions including tumorigenesis, metastasis, and drug resistance in human cancers. Oncogenic or tumor suppressor ncRNAs exert prominent effects on cell proliferation, migration and invasion in cancer cells through modulating various signaling pathways including Wnt/β-catenin. Upregulation of the oncogenic Wnt/β-catenin pathway was reported to be implicated in multiple human cancers including breast, liver, colorectal, and urothelial cancers. Therefore, identifying interactions between ncRNAs and canonical Wnt signaling components may represent novel therapeutic targets for better treatment and management of cancer. In this review, we summarized the recent findings about miRNA/lncRNA-dependent mechanisms that regulate Wnt/β-catenin signaling involved in tumorigenesis and metastasis of urinary tract cancers.