Assembly of a spatial circuit of T-bet–expressing T and B lymphocytes is required for antiviral humoral immunity
Alejandra Mendoza, William T. Yewdell, Beatrice Hoyos, Michail Schizas, Regina Bou-Puerto, Anthony Michaels, Chrysothemis C. Brown, Jayanta Chaudhuri, Alexander Y. Rudensky
Abstract
cells represent a specialized stable sublineage required for GC growth but dispensable for IgG2c class switching. Our studies show that during respiratory viral infection, T-bet-expressing T and B lymphocytes form a circuit assembled in a spatiotemporally controlled manner that acts as a functional unit enabling a robust and coherent humoral response tailored for optimal antiviral immunity.
Topics & Concepts
BiologyGerminal centerHumoral immunityPriming (agriculture)B cellImmunologyImmunityAcquired immune systemCell biologyImmune systemAntibodyBotanyGerminationT-cell and B-cell ImmunologyImmune Response and InflammationImmune Cell Function and Interaction