Tinctoric acid A-B, two new hopan-type triterpenoids from the Vietnamese lichen, <i>Parmotrema tinctorum</i> (Despr. ex Nyl.) hale with α-glucosidase inhibitory activity
Le-Thuy-Thuy-Trang Hoang, Hoang-Vinh-Truong Phan, Hoai-Vu Nguyen-Si, Thanh-Nha Tran, Thi‐Phi‐Giao Vo, Huong Thi Thu Le, Ngoc-Van-Trang Dao, Thi-Minh-Suong Huynh, Dinh‐Tri Mai, Phan-Si-Nguyen Dong, Van‐Kieu Nguyen
Abstract
Two new hopan-type triterpenoids, namely tinctoric acid A-B (1-2), were isolated from the lichen Parmotrema tinctorum (Despr. ex Nyl.) Hale. Their structures were elucidated by extensive spectroscopic analyses (1D and 2D NMR). The absolute configuration at C-22 of 1 was established through DP4 probability. Compounds 1-2 were evaluated for their inhibitory activity against α-glucosidase and found to be more potent than those of positive control (acarbose, IC50 168 µM) with values IC50 74.7 and 98.2 µM, respectively. Both of these compounds interacted well with enzyme α-glucosidase MAL32 through H-bonds and hydrophobic interaction.