Ameliorative Effects of Peptide Phe-Leu-Ala-Pro on Acute Liver and Kidney Injury Caused by CCl<sub>4</sub> via Attenuation of Oxidative Stress and Inflammation
Shuqi He, Wei Zhao, Xiang Chen, Jie Li, Leifang Zhang, Huoxi Jin
Abstract
-PI3K) in the liver and kidneys were significantly up-regulated after FLAP treatment. FLAP down-regulated the levels of interleukin-6 (IL-6), IL-1β, tumor necrosis factor-α (TNF-α), and nuclear factor-κ B (NF-κB) in liver and kidney tissues. Thus, FLAP may play a protective role in ALI and AKI by attenuating oxidative stress and inflammation mediated by the Nrf2/anti-response element (ARE) and PI3K/AKT/NF-κB pathways.
Topics & Concepts
Oxidative stressSuperoxide dismutaseGlutathione peroxidaseEndocrinologyCatalaseInternal medicineProtein kinase BCreatinineKidneyMedicineAcute kidney injuryInflammationChemistryGlutathioneLiver injuryBiochemistrySignal transductionEnzymeDrug-Induced Hepatotoxicity and ProtectionLiver Disease and TransplantationLiver Disease Diagnosis and Treatment