Palladium-Catalyzed Carbonylative Synthesis of Polycyclic 3,4-Dihydroquinolin-2(1<i>H</i>)-one Scaffolds Containing Perfluoroalkyl and Carbonyl Units
Shangyuan Wang, Jiajun Zhao, Jun Ying, Xiao‐Feng Wu
Abstract
A palladium-catalyzed one-pot two-step radical mediated carbonylative cyclization of 1,7-enynes with perfluoroalkyl iodides and Mo(CO) 6 has been developed for the construction of polycyclic 3,4-dihydroquinolin-2(1 H )-one scaffolds. This method realizes a facile synthesis of various polycyclic 3,4-dihydroquinolin-2(1 H )-one derivatives containing perfluoroalkyl and carbonyl units in high yields. Moreover, modifications of several bioactive molecules were demonstrated using this protocol.
Topics & Concepts
ChemistryPalladiumCatalysisCarbonylationCombinatorial chemistryMoleculeOrganic chemistryCarbon monoxideCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques