Design, synthesis and antitumor activity of 4-arylamine substituted pyrimidine derivatives as noncovalent EGFR inhibitors overcoming C797S mutation
Yaqing Zuo, Zhiwu Long, Rongrong Li, Yi Le, Silong Zhang, Huan He, Longjia Yan
Topics & Concepts
T790MChemistryEGFR inhibitorsEpidermal growth factor receptorOsimertinibCancer researchPharmacologyApoptosisBiochemistryReceptorGefitinibMedicineErlotinibLung Cancer Treatments and MutationsCancer therapeutics and mechanismsHER2/EGFR in Cancer Research