Licorice extract-infused electrospun nanofiber scaffold for wound healing
Md. Abdus Shahid, Md. Shablu Khan, Md. Mehedi Hasan
Abstract
Recently, nanofibers filled with various kinds of components from herbal extracts have been developed for use in wound healing. In this study, nanofiber scaffolds were developed from different mixing ratios of licorice (Glycyrrhiza glabra) extract and polyvinyl alcohol (PVA) by electrospinning. It was determined that the developed PVA-licorice nanofiber (PLN) scaffold showed outstanding antibacterial efficacy against Staphylococcus aureus (S. aureus), forming a 15 mm inhibitory zone against the bacterial cell. Only a small proportion of cells survived after contact to the substance on the vero cell line, according to in vitro cytotoxicity testing of it. Scanning electron microscopy (SEM), fourier transform infrared radiation (FT-IR), thermogravimetric analysis (TGA), and moisture management tester (MMT) were also used to analyze the morphological structure, compositional analysis, thermal behavior, and moisture management properties of the fabricated scaffolds, respectively. Average fiber diameter and pore size of the developed PLN scaffolds were measured from SEM images. The presence of licorice components in PLN scaffolds were confirmed by FT-IR spectra analysis. According to MMT, the created sample with maximum licorice concentration has better absorption characteristics, suggesting it could be a good candidate for wound healing.