Nicotinonitrile-derived apoptotic inducers: Design, synthesis, X-ray crystal structure and Pim kinase inhibition
Shaimaa M. Aboukhatwa, Amera O. Ibrahim, Hiroshi Aoyama, Ahmed S. Al-Behery, Moataz A. Shaldam, Ghada El-Ashmawy, Haytham O. Tawfik
Topics & Concepts
ChemistryCytotoxic T cellStaurosporineKinaseADMEApoptosisIC50Docking (animal)BiochemistryIn vitroProtein kinase ANursingMedicineCancer Mechanisms and TherapySynthesis and biological activitySynthesis and Characterization of Heterocyclic Compounds