The WD40-repeat protein WDR-48 promotes the stability of the deubiquitinating enzyme USP-46 by inhibiting its ubiquitination and degradation
Molly Hodul, Rakesh Ganji, Caroline L. Dahlberg, Malavika Raman, Peter Juo
Abstract
destabilizes USP46 in mammalian cells. Together, these results support a model in which WDR-48 binds and stabilizes USP-46 protein levels by preventing the ubiquitination and degradation of USP-46 in the proteasome. Given that a large number of USPs interact with WDR proteins, we propose that stabilization of DUBs by their interacting WDR proteins may be a conserved and widely used mechanism that controls DUB availability and function.
Topics & Concepts
Deubiquitinating enzymeUbiquitinCell biologyChemistryEnzymeProtein degradationDegradation (telecommunications)BiochemistryBiologyGeneComputer scienceTelecommunicationsUbiquitin and proteasome pathwaysAutophagy in Disease and TherapyGenetics and Neurodevelopmental Disorders