Single-cell sequencing provides insights into the landscape of ovary in PCOS and alterations induced by CUMS
Wenting Zuo, Xiangfei Liu, Jianhuai Chen, Wenren Zuo, Yanyun Yin, Xiaowei Nie, Peipei Tang, Yunke Huang, Qian Yu, Qiaoyun Hu, Jie Zhou, Yong Tan, Xi Huang, Qingling Ren
Abstract
In this study, we mapped the landscape of polycystic ovary syndrome (PCOS) ovary with rat model induced by letrozole and provided a novel insight into the molecular mechanism of PCOS accompanied by chronic unpredicted mild stress (CUMS) at single-cell transcriptomic level. These observations highlight the importance of inflammation in the pathogenesis of PCOS, which might also be the bridge between PCOS and psychological diseases.
Topics & Concepts
Polycystic ovaryInflammationEndoplasmic reticulumEndocrinologyInternal medicineBiologyTranscriptomeOvaryUnfolded protein responseCellGene expressionGeneCell biologyMedicineInsulin resistanceInsulinGeneticsOvarian function and disordersReproductive System and PregnancyOvarian cancer diagnosis and treatment