Targeting of antithrombin in hemophilia A or B with investigational siRNA therapeutic fitusiran—Results of the phase 1 inhibitor cohort
John Pasi, Toshko Lissitchkov, Vasily Mamonov, Tim Mant, Margarita Timofeeva, Catherine Bagot, Pratima Chowdary, Pencho Georgiev, Liana Gercheva, Kate Madigan, Huy Van Nguyen, Qifeng Yu, Baisong Mei, Craig C Benson, Margaret V. Ragni
Topics & Concepts
MedicineAdverse effectAntithrombinHaemophiliaQuality of life (healthcare)Internal medicineHemostasisPharmacodynamicsFactor IXPharmacokineticsCohortGastroenterologySurgeryHeparinNursingHemophilia Treatment and ResearchBlood Coagulation and Thrombosis MechanismsCoagulation, Bradykinin, Polyphosphates, and Angioedema